Noun the act of making someone unconscious.'' The boxer scored a knockout on his opponent. something wildly popular, entertaining, or funny If you've ever had a sack race, you know it's a real knockout for kids and adults alike. a partially punched opening meant for optional later removal They left a knockout in the panel for running extra wires someday. The deactivation of a particular gene a printing term for when a foreground color causes a background color not to print Adjective rendering someone unconscious He delivered a knockout blow. stunning; amazing; gorgeous You should have seen her knockout eyes. Related terms knock knock one's socks off knock out